图1 开题报告网站首页
图2 In vivo microglia-specific lineage tracing does not support the microglia-to-neuron conversion.
图3 Lentivirus induces non-specific labeling in vivo, which may confound the microglia-to-neuron observation.
图4 Even under microglia depleted brain, the “microglia-converted neurons” are detected, reflecting a lentiviral leakage artifact.
图5 该研究主要结论的总结。
换/移植小胶质细胞失控的分子开关
原稿下载链接：
//www.cell.com/neuron/fulltext/S0896-6273(21)00944-2
附：彭勃研究组2018-2022年发稿的代表着性论文范文
(1) Rao Y.*, Du S., Yang B., Wang Y., Li Y., Li R., Zhou T., Du X., He Y., Wang Y., Zhou X., Yuan T.-F.*, Mao Y.* and Peng B.* (2021) NeuroD1 induces microglial apoptosis and cannot induce microglia-to-neuron cross-lineage reprogramming, Neuron, 109.
(2) Huang Y.#, Xu, Z.#, Xiong S., Sun F., Qin G., Hu G., Wang J., Zhao L., Liang Y.-X., Wu T., Lu Z., Humayun M.S., So K.-F., Pan Y., Li N., Yuan T.-F.*, Rao Y.* and Peng B.* (2018). Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion. Nature Neuroscience 21, 530-540.
(3) Xu Z.#, Rao Y.#, Huang Y., Zhou T., Feng R., Xiong S., Yuan T.F., Qin S., Lu Y., Zhou X., Li X., Qin B., Mao Y., and Peng B.* (2020). Efficient strategies for microglia replacement in the central nervous system. Cell Reports 32, 108041.
(4) Huang Y.#, Xu Z.#, Xiong S., Qin G., Sun F., Yang J., Yuan T.F., Zhao L., Wang K., Liang Y.X., Fu L., Wu T., Lu Z., So K.F., Rao Y.* and Peng B.* (2018) Dual origins of retinal microglia in the model of microglia repopulation. Cell Discovery 4, 9.
(5) Xu, Z., Zhou, X., Peng, B.*, and Rao, Y.* (2021). Microglia replacement by bone marrow transplantation (Mr BMT) in the central nervous system of adult mice. STAR Protocols 2, 100666.
(6) Xu, Z., Rao, Y.*, and Peng, B.* (2021). Protocol for microglia replacement by peripheral blood (Mr PB). STAR Protocols 2, 100613.
(7) Xu, Z., ;Peng, B.*, and Rao, Y.* (2021). Microglia replacement by microglia transplantation (Mr MT) in the adult mouse brain. STAR Protocols 2, 100665.
考虑期刊论文
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